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37 Senescent fibroblasts promote degradation of the extracellular matrix (ECM) by secreting matrix metalloproteinase-1 (MMP1) and other proinflammatory factors, 38 ultimately leading to thinning of the epidermis and decreased barrier function, 39 while the selective removal of senescent cells leads to normalization of the ECM and a reduction in inflammation

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Its components, BPC-157, KPV, “GHK-Cu (for injectable routes of administration)” and “Thymosin beta-4, fragment (LKKTETQ), also known as TB-500, appeared on the FDA’s list of bulk drug substances nominated but withdrawn for use in compounding under section 503A